what are you recording?
1st - check your cables (PL, XLR, RCA). usually defective cables can cause this
2nd - plug the power cable of your m-audio and pc sa AVR or UPS
- yan din naging problem ng kaibigan ko before cause hindi grounded yung kuryente nila.
try yo check din yung PSU ng cpu mo if its a desktop pc. karaniwan pag generic PSU lang nag cacause din ng noise sa recording eh