I tried to clean out my pedalboard one time, and tried out a more traditional "daisy chain" setup, as follows:
guitar -> DOD Milkbox Compressor -> Joyo Vintage Overdrive -> MI Audio Tube Zone -> EHX Small Clone -> AMZ MOSFET Boost -> TC Electronic Flashback -> amp
It turns out that, while the Milkbox's buffer made my signal better when on its own, I found that it introduced a lot of noise into my signal when I turned on the drive pedals. Taking the Milkbox out completely made the signal sound quieter, but I needed a compressor on all the time for my cleans, so I hooked everything up using the old A/B switcher way.
On a side note, having a looper BEFORE all your other pedals can serve as a limited sort of reamping device, which can help with tweaking your settings to approach the sounds you hear from records more accurately. It's slightly more difficult to do it when you're busy playing your guitar AND turning knobs on your pedals.