Kung isang gitara lang talaga, hands down the Strat. It's not just that it's super versatile, but the tones you can get are pretty endless. pup switch pa lang ulam na eh, tapos galawin mo pa yung tone knobs.
I'd pick a tele, pero kung isa lang talaga at wala nang iba, strat, kahit ayoko ng strat. But give me a fat strat.
If the brand wasn't an issue though, Epiphone Wilshire (got to try one out, ayos).