What Big Muff are you referring to? The one with the silver metal chassis and red 'pi' logo at the center?
Yeah, I think I've heard that particular unit from a friend of mine.. and it sure sounds good even as a stand-alone unit .. with another od before it, I'm sure it sounds great
For me, one of the best combos I've tried so far are the ProCo Rat 2 boosted by another overdrive: particularly an SD-1, a Vox Valvetone or a modded TS-9.
Funny thing is, much as I'd love to rave to no end about this or that particular combination, over the years, I've noticed that my 'taste' always changes. And it always varies from jam to jam.. Sometimes, a certain combination sounds better for a particular day. At other times, what seems to be your 'favorite' pair just doesn't seem to cut it at all ..
What knocks me even further is that, sometimes, you come across something that you haven't used for some time and viola! ... it works just like magic!
Sometimes, you dial in such a nice setting with just your guitar straight to an amp and you feel that you don't even need an overdrive to sound great ..
With so many variables to take into account, I'd be reluctant to peg my tone on just a few pedals ...
It depends on the gig, I guess ..