I'll share my personal tips for those who's into high gain(metal) stuff.
Out of the 3 noise gates, (ZNR, NoiseGate, DirtyGate), i found the Dirty Gate the tightest without sacrificing much sustain at your preferred threshold. I always put my gate at the start of the chain to maintain fixed threshold level.
Do you feel like you're lacking hi-mids but when you dial the treble on the drive pedal/amp simulator, it sounds too nasal or harsh?
try adding Bit Crush after the amp sim on the signal chain.
I set Bit to 16, Bal from 20-30,
and set the SMPL(sampling rate) to your taste - this is where you boost certain hi-mid frequencies.
and lastly post-eq using GraphicEQ, cut the 3.2kHz, -2dB to -5dB to taste, the most annoying guitar freq lies around 2-4kHz and mostly they cut on studio recordings.
Enjoy!