This question just about describes my setup
To wit:
Guitar:
'06 MIM Standard Strat - My guitar of choice, for its tone and feel
Stompboxes:
1. Morley Mini Wah - For those occasional funk tunes or solos with a wah
2. MI Audio Tube Zone - My Mesa Boogie Mark series in a box
3. MXR/CAE Boost/Line Driver - To boost myself to the top when soloing
Amp:
Roland Blues Cube 60 - Almost tube amp tone and feel without the tube amp maintenance hassle