Just recently got a Boss Me-33 via trade. I'm using a hybrid setup, connecting the Me-33 to a Boss DD3, A Sansamp Clone and a Boss SD1.
Read through the forums that the multieffects sucks down the tone of the analog pedals which is true. Confirmed it by using the bypass function of the Me-33 and comparing the bypass tone to the hybrid tone.
So in order to fix the situation, i used the EQ effect of the Me-33 and tweaked the EQ settings to bring back the lost tone which was sucked by the ME-33 and VIOLA! as if i was using straight analog pedals.
Modulations are really good, im currently using the delay, phaser, chorus and flanger modulations, sounded really solid. Distortion and The Amp Simulator sucked as hell.
Took me time to figure out the thing but once you got it, its like your bringing 4 stomp boxes with you.
Haven't tried it out at gigs but as of now, i'm really loving the Boss ME-33, really a good buy!