Ako gamit ko tube amp tapos my gadget are also have tube, my amp is a fender blues deluxe tapos my gadgets are the one called a bk butler tube driver and a ehx wiggler. it's not komplikado naman, it's very nice anyway. if sound is good or bad tingin ko it is determinant by the one called the guitar player...
Seriously, whether I plug my Tube Driver to a Solid state (that's what you call amps without tubes in them) or to a tube amp, with the proper tweaking it sounds 90% the same.
And yes, before asking questions here try looking for the answer first yourself. Google is your friend.