Proper EQ to prevent feedback.
IMHO, Sir, proper mic and speaker placement, proper gain structure, proper monitoring, to mic your backline or to house your instruments using DI boxes, keeping the no. of open mics at a minimum kung pwede, etc. should all be attended first, i.e., drawing the best from the sound source itself at their given location. Pag nailatag na lahat observing sound acoustic principles and good sound reinforcement practices, perhaps we can attend to the board EQ for individual source (mic or instrument) tweaks as needed and, as you mentioned, the house system EQ for how that setup would respond to the room. What do you think po?