Nice thread! Pwede na sigurong i-merge yung tips and EQ guide na thread dito.
As for my EQ setting, since 2-Channels. Channel 1 goes to the FX loop of the POD and Channel 2 goes after the POD, before the Powered Speaker. Channel 2 is mostly for 'on-the-fly' tweak as per different venues and rooms.
All frequencies not entirely passed by the guitar tone is on -12dB, especially on 20-40Hz on bass and 10-16kHz on high frequencies to not color the sound on subtle situations on live setting.
My favorite EQ setting is about 6dB boost on low-mid, mid, and high-mid Frequency for that punchy tone and slight presence especially on leads.